Publications by authors named "R L Glass"
Aim: To evaluate the impact of a participatory, action-oriented implementation study, guided by the integrated Promoting Action on Research Implementation in Health Services framework, for optimising pain care processes in a tertiary paediatric emergency department.
Design: Hybrid type 3 implementation effectiveness.
Methods: A collaborative appraisal of the context and culture of pain care informed two interdependent action cycles: Enabling nurse-initiated analgesia and involving families in pain care.
Article Synopsis
- The study highlights how the DNA damage response (DDR) and blood-tumor barrier (BTB) hinder chemotherapy effectiveness in glioblastomas, resulting in frequent relapses.
- It reveals that the interplay between glioblastoma cells and myeloid cells activates GP130 receptor signaling, causing resistance to the chemotherapy drug temozolomide (TMZ) at both genetic and vascular levels.
- The research suggests that blocking GP130 can reduce DDR activity and BTB formation, potentially enhancing the effectiveness of chemotherapy for GBMs with the identification of predictive markers.
Background: The translocator protein (TSPO) has been proven to have great potential as a target for the positron emission tomography (PET) imaging of glioblastoma. However, there is an ongoing debate about the potential various sources of the TSPO PET signal. This work investigates the impact of the inoculation-driven immune response on the PET signal in experimental orthotopic glioblastoma.
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- Brain pericytes help control blood flow in the brain and keep the protective barrier around it strong, but they may also play a role in fighting brain infections.
- In this study, scientists looked at how pericytes react to a specific brain infection caused by a bacteria called Streptococcus pneumoniae using both lab tests and animal models.
- The results showed that when pericytes were removed from zebrafish and mice, the animals experienced more brain swelling and worse outcomes during the infection, suggesting that pericytes are important for protecting the brain during sickness.
The controlled electrochemical deposition of hydrogels from low-molecular weight hydrogelators (LMWHGs) allows for the defined formation of thin films on electrodes. Here, the deposition of fibrillar networks consisting of ,',″-tris(4-carboxyphenylene)-1,3,5-benzenetricarboxamide (BTA) onto ultraflat gold electrodes has been studied. This process, also termed electrogelation, is based on a local change in the pH due to electrolysis of water at the electrode.
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