Agomelatine protects against neuronal damage without preventing epileptogenesis in the kainate model of temporal lobe epilepsy.

Recent studies about the novel antidepressant agomelatine, which is a mixed MT and MT melatonin receptor agonist and 5HT serotonin receptor antagonist possessing an anticonvulsant and neuroprotective action, suggest that it may have potential to contribute against epileptogenesis and epilepsy-induced memory impairment. In order to ascertain whether protection of some brain structures could suppress epileptogenesis, in the present study, we evaluated the effect of chronic post-status treatment with agomelatine on epileptogenesis, behavioral and neuronal damage induced by kainate acid (KA) status epilepticus (SE). Agomelatine/vehicle treatment (40mg/kg, i.

Effects of nutrients on the production of AK-111-81 macrolide antibiotic by Streptomyces hygroscopicus.

The influence of different carbon and nitrogen sources on the production of AK-111-81 nonpolyenic macrolide antibiotic by Streptomyces hygroscopicus 111-81 was studied. Substitution of glucose with lactose or glycerol significantly affected maximal antibiotic AK-111-81 productivity as the growth rate was close to that of the basal fermentation medium. Addition of ammonium succinate to the fermentation medium markedly increased the antibiotic productivity as the growth rate was low.

Physiological and antagonistic potential of actinomycetes from loquat rhizosphere.

The microflora of Eriobotrya japonica (loquat) was studied by the serial dilutions-spread plate method. A variety of bacteria, fungi and actinomycetes was detected. The genus Steptomyces dominated in the population (83%).

Comparative investigation of a streptovaricin-producing strain of Streptomyces spectabilis and its selectant.

Some differences were found in the ultrastructural, cultural and physiological-biochemical properties between the parent strain Streptomyces spectabilis 1000 and its natural selectant S. spectabilis 1011-10, producers of streptovaricin.

Streptomyces species producing the streptovaricin complex.

Morphological, cultural and physiological-biochemical properties of Streptomyces sp. strain 1000 and its antibiotic production were investigated. Antibiotics 1011 (identical with the streptovaricin complex) and 1012 (with antibacterial action) were isolated from the cultural broth of this strain.