Generalization of Interarticulator Timing Control: Evidence From Tongue-Jaw and Lip-Jaw Kinematics Using Electromagnetic Articulography.

Background: In skilled speech production, the motor system coordinates the movements of distinct sets of articulators to form precise and consistent constrictions in the vocal tract at distinct locations, across contextual variations in movement rate and amplitude. Research efforts have sought to uncover the critical control parameters governing interarticulator coordination during constriction formation, with a focus on two parameters: (a) latency of movement onset of one articulator relative to another (temporal parameters) and (b) phase angle of movement onset for one articulator relative to another (spatiotemporal parameters). Consistent interarticulator timing between jaw and tongue tip movements, during the formation of constrictions at the alveolar ridge, was previously found to scale more reliably than phase angles across variation in production rate and syllable stress.

Novel Application of Non-Invasive Methodological Approaches in Biomedical Sciences Towards Better Understanding of Marine Teleost Ocular Health and Disease.

Seafood is an important resource for global nutrition and food security, with both land and marine aquaculture playing pivotal roles. High visual acuity is key for health and survival of farmed, cultured, and wild fish. Cleaner fish technology to control parasite infestation has become important in marine aquaculture and highlights the importance of visual acuity in the efficacy of cleaner fish species.

JAK2V617F-dependent down regulation of SHP-1 expression participates in the selection of myeloproliferative neoplasm cells in the presence of TGF-β.

Myeloproliferative neoplasms (MPNs) are characterized by an increased production of blood cells due to the acquisition of mutations such as JAK2. TGF-β, whose secretion is increased in MPN patients, is known to negatively regulate haematopoietic stem cell (HSC) proliferation. Using an isogenic JAK2 or JAK2 wild-type UT-7 cell line we observed that JAK2 cells resist to TGF-β antiproliferative activity.

Transcriptomic response of lumpfish () head kidney to viral mimic, with a focus on the family.

The economic importance of lumpfish () is increasing, but several aspects of its immune responses are not well understood. To discover genes and mechanisms involved in the lumpfish antiviral response, fish were intraperitoneally injected with either the viral mimic polyinosinic:polycytidylic acid [poly(I:C)] or phosphate-buffered saline (PBS; vehicle control), and head kidneys were sampled 24 hours post-injection (hpi) for transcriptomic analyses. RNA sequencing (RNA-Seq) (adjusted p-value <0.

Increased water temperature contributes to a chondrogenesis response in the eyes of spotted wolffish.

Adult vertebrate cartilage is usually quiescent. Some vertebrates possess ocular scleral skeletons composed of cartilage or bone. The morphological characteristics of the spotted wolffish (Anarhichas minor) scleral skeleton have not been described.