Publications by authors named "R L Duncan"
Introduction: In the United States, sport is a common form of youth physical activity (PA) with demonstrated health benefits. However, limited longitudinal dataexists on the psychosocial determinants and consequences of youth sport participation. This study examined grade 6 (11-12-year-old) predictors of high school organized sport participation and effects of high school sport participation on age 26 behavior, mental health and wellbeing.
View Article and Find Full Text PDFBackground/objectives: Anterior Gradient-2 (AGR2/PDIA17) is a member of the protein disulfide isomerase (PDI) family of oxidoreductases. AGR2 is up-regulated in several solid tumors, including pancreatic ductal adenocarcinoma (PDAC). Given the dire need for new therapeutic options for PDAC patients, we investigated the expression and function of AGR2 in PDAC and developed a novel series of affinity-matured AGR2-specific single-chain variable fragments (scFvs) and monoclonal antibodies.
View Article and Find Full Text PDFAim: To ascertain the current evidence about the support, education and learning needs of experienced registered nurses who are transitioning their work to intensive care nursing as a new context.
Design: A scoping review was conducted using established frameworks from JBI, Arksey and O'Malley.
Methods: A search was conducted in CINHAL and MEDLINE (April 2023).
Article Synopsis
- Reproducibility is crucial in science as it boosts confidence in findings and enables comparison of data, yet evaluating it can be challenging, especially with RNA sequencing (RNA-seq) where multiple steps can introduce variance.
- This study specifically examines the reproducibility of gene expression data from bacteria in cystic fibrosis models, utilizing samples from three labs and different sequencing pipelines to draw comparisons.
- The results indicate high reproducibility of gene expression across labs, despite some variance introduced by different sequencing methods, with both pipelines detecting over 80% of the same differentially expressed genes, confirming the validity of RNA-seq data comparisons.
Background: Adverse events (AEs) associated with vaccination have traditionally been evaluated by epidemiological studies. More recently, they have gained attention due to the emergency use authorization of several COVID-19 vaccines. As part of its responsibility to conduct postmarket surveillance, the US Food and Drug Administration continues to monitor several AEs of interest to ensure the safety of vaccines, including those for COVID-19.
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