Publications by authors named "R L Carhart-Harris"
This study aimed to investigate differences in long-term psychological effects, acute subjective effects, and side effects associated with psychedelic use in adolescents (aged 16-24), compared with adults (aged 25+). Data from two observational online survey cohorts was pooled, involving adolescents (average age 20.4 ± 2.
View Article and Find Full Text PDFBackground: Psilocybin therapy (PT) produces rapid and persistent antidepressant effects in major depressive disorder (MDD). However, the long-term effects of PT have never been compared with gold-standard treatments for MDD such as pharmacotherapy or psychotherapy alone or in combination.
Methods: This is a 6-month follow-up study of a phase 2, double-blind, randomised, controlled trial involving patients with moderate-to-severe MDD.
Objective: To determine the relationships between psilocybin dose, psychedelic experiences, and therapeutic outcome in treatment-resistant depression.
Methods: For treatment-resistant depression, 233 participants received a single dose of 25, 10, or 1 mg of COMP360 psilocybin (a proprietary, pharmaceutical-grade synthesized psilocybin formulation, developed by the sponsor, Compass Pathfinder Ltd.) with psychological support.
Article Synopsis
- Serotonergic psychedelics, like LSD and psilocybin, alter consciousness and may help treat mental health issues, but how they work is still not entirely clear.
- The study reviews subjective experiences, neuroimaging, and molecular actions, indicating LSD leads to more intense visionary experiences compared to psilocybin and alters brain connectivity patterns.
- Findings suggest a complex relationship between different psychedelics' effects and highlight the need for standardized research methods to better understand these substances and their therapeutic potential.*
Article Synopsis
- Psilocybin, found in magic mushrooms, is being researched for its potential benefits on mental health, with focus growing on its naturalistic use in real-world settings.
- The study aimed to assess how naturalistic psilocybin use affects health outcomes and experiences differently for White individuals compared to Participants of Color.
- Results showed that race/ethnicity influenced the effects of psilocybin on outcomes like spiritual wellbeing, cognitive flexibility, and emotion regulation, suggesting that context of use may vary across different racial groups.