The Social Return on Investment in programs designed for young people living with a family member who experiences mental health challenges: study protocol.

The purpose of this paper is to describe the protocol for the evaluation of programs offered by the Satellite Foundation, designed for, and with, children and young people aged between 8 and 25 years who have family members experiencing mental health challenges. To achieve this, the Social Return on Investment (SROI) method was chosen. SROI is an economic measurement tool used to apply a monetary value to socially situated outcomes.

Exploring the Complex Relationship Between Psychosocial Stress and the Gut Microbiome: Implications for Inflammation and Immune Modulation.

There is growing interest in understanding the complex relationship between psychosocial stress and the human gastrointestinal microbiome (GIM). This review explores the potential physiological pathways connecting these two and how they contribute to a pro-inflammatory environment that can lead to the development and progression of the disease. Exposure to psychosocial stress triggers the activation of the sympathetic nervous system (SNS) and hypothalamic-pituitary axis (HPA), leading to various physiological responses essential for survival and coping with the stressor.

Comparison of Partially Denatured Cytochrome Structural Ensembles in Solution and Gas Phases Using Cross-Linking Mass Spectrometry.

Electrospray ionization mass spectrometry (ESI-MS) can retain intact protein structures, but details about partially folded and unfolded protein structures during and after introduction to the gas phase are elusive. Here we use ESI-MS with chemical cross-linkers to compare denatured cytochrome structures in both solution and gas phases. Solution phase cross-linking prior to ESI captures solution phase structures, while gas phase cross-linking through ion/ion reactions in the trap cell captures gas phase structures.

Human Needs in Relation to Home Attachment: Towards a Theoretical Framework to Architectural Affordances in Temporary Accommodation to Aid Designers.

The current and rising provision of temporary accommodation in the UK does not always meet the needs of residents with one such contributing factor being the often-poor atmospheric qualities within these environments. Temporary accommodation is a broad term for housing provided for those who have previously been homeless, covering different variations of support or tenancy length. Our research synthesises transdisciplinary literature to create a theoretical framework which can be used to inform the design of suitable temporary accommodation by connecting psychological theories in a novel way to shed light on the parameters of the phenomenon of home attachment, specifically physical, architectural elements.