Diverse NKT cells regulate early inflammation and neurological outcomes after cardiac arrest and resuscitation.

Neurological injury drives most deaths and morbidity among patients hospitalized for out-of-hospital cardiac arrest (OHCA). Despite its clinical importance, there are no effective pharmacological therapies targeting post-cardiac arrest (CA) neurological injury. Here, we analyzed circulating immune cells from a large cohort of patients with OHCA, finding that lymphopenia independently associated with poor neurological outcomes.

Advanced pullulan nanofibers reinforced by cellulose fibrils as drug carriers for salicylic acid.

The goal of the current work is to showcase the synthesis of homogeneous pullulan nanofibers that are strengthened by the addition of cellulose nanofibrils (CNF). One of the main difficulties this study faced was determining the ideal water/organic solvent ratio for the electrospinning process, which would allow for the maximum reduction in the amount of organic solvent (DMF or DMSO) needed. The rheological behavior of electrospinning solutions was modulated by varying both, the pullulan concentration and solvent system composition.

Calorie restriction induces mandible bone loss by regulating mitochondrial function.

Caloric restriction (CR), commonly used as both a lifestyle choice and medical strategy, has been shown to adversely impact appendicular bone mass. However, its influence on alveolar bone health and the underlying mechanisms remain poorly understood. In this study, 8-week-old C57BL/6 J mice were fed with 30 % CR for 8 weeks.