Publications by authors named "R L Anders"
The cholangioblastic variant of intrahepatic cholangiocarcinoma is a distinctive neoplasm that typically affects young women without underlying liver disease. Morphologically, it demonstrates solid, trabecular, and tubulocystic architecture, biphasic small cell-large cell cytology, and immunoreactivity for inhibin, neuroendocrine markers, and biliary but not hepatocellular markers. In 2021, our group identified a characteristic NIPBL::NACC1 gene fusion in cholangioblastic cholangiocarcinoma, and since then ~20 genetically confirmed cases have been reported in the literature.
View Article and Find Full Text PDFSuccessful pancreatic ductal adenocarcinoma (PDAC) immunotherapy requires therapeutic combinations that induce quality T cells. Tumor microenvironment (TME) analysis following therapeutic interventions can identify response mechanisms, informing design of effective combinations. We provide a reference single-cell dataset from tumor-infiltrating leukocytes (TILs) from a human neoadjuvant clinical trial comparing the granulocyte-macrophage colony-stimulating factor (GM-CSF)-secreting allogeneic PDAC vaccine GVAX alone, in combination with anti-PD1 or with both anti-PD1 and CD137 agonist.
View Article and Find Full Text PDFBackground: Police officers constitute a work force at high risk due to their highly demanding work conditions. In a realistic paradigm, these conditions, and other determinants of their psychological health, can be linked to a multitude of variables that interplay altogether. However, current literature that simultaneously models-quantitatively from observed data-such a multitude of variables is sparse.
View Article and Find Full Text PDFArticle Synopsis
- Gastric carcinomas (GCs) are aggressive cancers, with only 15% of patients responding to anti-PD-(L)1 treatments, but those associated with Epstein-Barr virus (EBV) exhibit better responses and unique immune characteristics.
- A study analyzed tumor immune microenvironments in 25 treatment-naïve GCs, comparing 11 EBV+ and 14 EBV- cases using immunohistochemistry and gene expression profiling.
- Results showed EBV+ GCs had higher densities of CD8+ T cells and distinct immune gene expression patterns, while EBV- GCs demonstrated increased inflammatory and immunosuppressive gene signatures, suggesting differing mechanisms of immune evasion.
Objective: What are young children trying to express when they cry at night? According to Sadeh, parental beliefs about why their child is crying may play a role in the development and persistence of their child's insomnia. The aim of this study was to create a scale that specifically assesses these parental interpretations in different dimensions.
Methods: Children aged between 6 months and 3 years with either good sleep habits or behavioural insomnia were recruited.