Disinfecting action of a new multi-purpose disinfection solution for contact lenses.

The disinfection activity of a new multipurpose disinfection solution (OPTI-FREE Express with ALDOX) was compared to several other contact lens disinfecting solutions. The new solution is preserved with polyquaternium-1 and myristamidopropyl dimethylamine. The other solutions included 3% hydrogen peroxide systems and multipurpose solutions (MPS) preserved with polyhexamethylene biguanide.

Amoebicidal activity of a preserved contact lens multipurpose disinfecting solution compared to a disinfection/neutralisation peroxide system.

The amoebicidal activity of a contact lens multipurpose disinfecting solution (MPDS) containing polyquaternium-1 and myristamidopropyl dimethylamine was compared to a disinfection/neutralisation peroxide system against Acanthamoeba castellanii and Acanthamoeba polyphaga trophozoites and cysts. A quantitative microtitre method was used to evaluate the solutions. The MPDS showed similar amoebicidal activity to the disinfection/neutralisation peroxide system against the trophozoites of both species and equal or more rapid activity against the cysts of both species.

Topical antibacterial therapy for mycobacterial keratitis: potential for surgical prophylaxis and treatment.

Background: Mycobacterium chelonae and Mycobacterium fortuitum are the 2 most commonly implicated species of nontuberculous mycobacteria in cases of bacterial keratitis.

Objectives: This article summarizes available data on the in vitro antibacterial activity against M chelonae or M fortuitum of 2 agents-amikacin and clarithromycin-that have been used in the treatment of bacterial keratitis. In addition, the article reviews the in vitro activity of 5 commercially available topical ocular fluoro-quinolones (in order of availability, ciprofloxacin, ofloxacin, levofloxacin, gatifloxacin, and moxifloxacin) that may have potential in the surgical prophylaxis and treatment of keratitis caused by M chelonae or M fortuitum.

Corneal ciprofloxacin precipitation during bacterial keratitis.

Purpose: To examine how age affects the risk of developing a white corneal precipitate during ciprofloxacin therapy for bacterial keratitis and to explore the effect of a white precipitate on rates of clinical improvement and cure.

Design: Prospective, multicenter, observational cohort study.

Methods: Occurrence of a white precipitate of the corneal surface was recorded among 624 patients with presumed bacterial keratitis who were treated with topical ciprofloxacin 0.

Influence of fluoroquinolone susceptibility on the therapeutic response of fluoroquinolone-treated bacterial keratitis.

Objective: To estimate how a corneal isolate's minimal inhibitory concentration for a fluoroquinolone agent affects the rate of clinical response of bacterial keratitis to fluoroquinolone therapy.

Design: Prospective cohort study.

Methods: Six hundred sixty-three individuals with suspected bacterial keratitis underwent diagnostic corneal scraping and were treated with topical 0.