[Connatal varicella embryo-fetopathy].

Connatal varicella embryo-fetopathy is rare. A newborn is described with severe cutaneous lesions, contractures, and hypoplasia of limbs following maternal varicella at the 13th week of pregnancy. Persisting low CF- and ELISA IgG-antibodies up to the age of 18 months give evidence for a prenatal varicella infection.

The effects of metoclopramide on acetylcholine release and on smooth muscle response in the isolated guinea-pig ileum.

The effects of metoclopramide on smooth muscle contraction and on release of acetylcholine were studied in the guinea-pig myenteric plexus longitudinal muscle preparation. Acetylcholine was determined either as endogenous acetylcholine, or as labelled transmitter from strips preloaded with 3H-choline. Metoclopramide caused an increase in resting tension of longitudinal muscle as well as an increase in resting output of either endogenous or labelled acetylcholine.

Choline inhibits acetylcholine release via presynaptic muscarine receptors.

The effect of exogenous choline on the outflow of 3H-acetylcholine evoked by field stimulation was studied on the myenteric plexus-longitudinal muscle preparation of the guinea pig. Choline at concentrations of 100 microM and higher depressed the evoked outflow of 3H-acetylcholine in a concentration-dependent manner. The EC50 for the inhibitory action was 300 microM.