Publications by authors named "R Kralovics"
Article Synopsis
- Clonal hematopoiesis (CH) is a new cardiovascular risk factor linked to acquired mutations in hematopoietic stem cells, potentially impacting patients with carotid atherosclerosis.
- A study analyzed CH in 968 patients with asymptomatic carotid atherosclerosis through deep sequencing, finding that 13.7% had clonal markers, with higher prevalence in older patients.
- Results showed that the presence of CH significantly increased the risk of cardiovascular death, especially in older individuals and those with severe carotid stenosis, highlighting the importance of CH assessment for better prognostic evaluation.
Genetically engineered mouse models have the potential to unravel fundamental biological processes and provide mechanistic insights into the pathogenesis of human diseases. We have previously observed that germline genetic variation at the TULP4 locus influences clinical characteristics in patients with myeloproliferative neoplasms. To elucidate the role of TULP4 in pathological and physiological processes in vivo, we generated a Tulp4 knockout mouse model.
View Article and Find Full Text PDFMyeloproliferative neoplasms (MPN) are characterized by uncontrolled expansion of myeloid cells, disease-related mutations in certain driver-genes including JAK2, CALR, and MPL, and a substantial risk to progress to secondary acute myeloid leukemia (sAML). Although behaving as stem cell neoplasms, little is known about disease-initiating stem cells in MPN. We established the phenotype of putative CD34 /CD38 stem cells and CD34 /CD38 progenitor cells in MPN.
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