Publications by authors named "R Koyama"
Effective use of dupilumab for eosinophilic gastritis concomitant with severe asthma.
Allergy Asthma Clin Immunol
December 2024
Background: Eosinophilic gastrointestinal diseases (EGIDs) are chronic immune-mediated inflammatory disorders characterized by gastrointestinal symptoms and eosinophilic inflammation in specific regions of the gastrointestinal tract. "Eosinophilic gastritis" (EoG) refers to the condition in which the stomach is involved. In patients with EoG, approved treatment options are restricted despite the high mortality associated with the condition.
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- * Research identified that levels of Lingo2, a protein linked to excitatory synapse formation, were increased in neurons from the VPA model, suggesting its role as an excitatory synapse organizer.
- * The secreted form of Lingo2 (sLingo2) was found to enhance excitatory synapses in both mouse and human neurons, indicating that better understanding sLingo2's mechanisms could shed light on the development of ASD.
Article Synopsis
- A 71-year-old woman experienced severe allergic reactions, including anaphylaxis, after receiving an injection of JOYCLU, highlighting potential risks associated with the treatment.
- Although a basophil activation test (BAT) showed no positive findings, the case underscores the need for better testing methods and caution during JOYCLU administration, especially as OA cases increase.
Unilateral absence of the pulmonary artery (UAPA) is a rare congenital condition. When UAPA occurs without associated congenital heart disease, it is referred to as isolated unilateral absence of the pulmonary artery (IUAPA). IUAPA is frequently not diagnosed until adulthood.
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