Publications by authors named "R Kotchetkov"
Article Synopsis
- - Non-secretory multiple myeloma (NSMM) is a rare and hard-to-detect form of multiple myeloma that often lacks significant monoclonal protein production, complicating diagnosis.
- - Two patients undergoing treatment for multiple myeloma developed extramedullary masses that were biopsied and confirmed as non-secretory plasmacytomas, despite showing no measurable monoclonal proteins in their blood work.
- - Radiotherapy effectively treated the localized masses without altering the patients' ongoing systemic therapies, suggesting it's a viable option for managing NSMM relapses while maintaining other treatments.
Background: Essential Thrombocythemia is a chronic myeloproliferative neoplasm characterized by an isolated excessive production of platelets. Extreme thrombocytosis is defined by having a platelet count greater than or equal to 1,000 x 10/L, which may lead to the development of acquired von Willebrand syndrome and complications of excessive hemorrhage.
Case Description: A 74-year-old female patient was brought in for a bone marrow examination regarding elevated platelet count.
Myeloproliferative neoplasms (MPNs) are a group of chronic hematologic malignancies that lead to morbidity and early mortality due to thrombotic complications and progression to acute leukemia. Clinical and mutational risk factors have been demonstrated to predict outcomes in patients with MPNs and are used commonly to guide therapeutic decisions, including allogenic stem cell transplant, in myelofibrosis. Adolescents and young adults (AYA, age ≤45 years) comprise less than 10% of all MPN patients and have unique clinical and therapeutic considerations.
View Article and Find Full Text PDFWe present a case of lymphocytosis assumed and managed initially as a chronic lymphocytic leukemia. Shortly after initial visit, the patient's condition deteriorated rapidly with hepatosplenomegaly, pleural effusion, ascites, and skin lesions. Flow cytometry (FC) showed the presence of clonal T-cell population, reported as T-cell lymphoma.
View Article and Find Full Text PDFBackground: Dual hematological malignancies, asynchronous or synchronous, are underrecognized entities and are usually suspected when clinical, hematological, or biochemical features cannot be explained by the primary malignancy alone. We present a case of synchronous dual hematological malignancies (SDHMs), where the patient was diagnosed with symptomatic multiple myeloma (MM) and essential thrombocythemia (ET), when excessive thrombocytosis occurred following initiation of MPV (melphalan-prednisone-bortezomib) antimyeloma therapy.
Case Description: An 86-year-old woman presented to the emergency in May 2016 with confusion, hypercalcemia, and acute kidney injury.