Publications by authors named "R Kopp"
Global mean sea-level (GMSL) change can shed light on how the Earth system responds to warming. Glaciological evidence indicates that Earth's ice sheets retreated inland of early industrial (1850 CE) extents during the Holocene (11.7-0 ka), yet previous work suggests that Holocene GMSL never surpassed early industrial levels.
View Article and Find Full Text PDFHeat production in a stochastic system with nonlinear time-delayed feedback.
Phys Rev E
November 2024
Using the framework of stochastic thermodynamics we study heat production related to the stochastic motion of a particle driven by repulsive, nonlinear, time-delayed feedback. Recently it has been shown that this type of feedback can lead to persistent motion above a threshold in parameter space [R. A.
View Article and Find Full Text PDFAccording to the Extracorporeal Life Support Organization (ELSO) guidelines, pre-assembled and already primed extracorporeal membrane oxygenation (ECMO) systems can be safely stored for up to 30 days under specific conditions. This study gives a detailed overview of existing pre-assembly practices. An anonymous online survey was conducted among chief perfusionists at German ECMO centers.
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- Research highlights the genetic factors linked to schizophrenia (SCZ) through brain expression quantitative trait loci (eQTLs), primarily focusing on European populations, which limits insights into diverse populations.
- A comparative analysis across African Americans, Europeans, and East Asians revealed distinct eQTL patterns, with over 343,000 eQTLs unique to non-European groups, largely driven by differences in allele frequency.
- This study suggests that increasing diversity in genetic ancestry, rather than just sample size, can enhance understanding of SCZ's genetic basis and aid in identifying risk genes associated with the disorder.
Article Synopsis
- Advances in immuno-oncology have improved treatment for renal cell carcinoma, but patients with "primary refractory" disease have poor outcomes; our study found a 19% prevalence of this group among 1,709 metastatic clear cell patients across 72 centers in 22 countries.
- The highest primary refractory rate was 27% with nivolumab/ipilimumab, while pembrolizumab/lenvatinib had the lowest at 10%; those classified as primary refractory only had a median survival of 7.6 months compared to 55.7 months for non-primary refractory patients.
- Significant predictors of survival for primary refractory patients included factors like prior nephrectomy and presence of bone/brain metastases, highlighting the complex