A Critical and Intersectional Model of LGBTQ Microaggressions: Toward a More Comprehensive Understanding.

This article summarizes a proposed critical and intersectional model of LGBTQ microaggressions that can be used by scholars and practitioners from multiple disciplines. Drawing on critical and intersectional paradigms and decades of research from multiple fields, we constructed a model that acknowledges the breadth, depth, scope, and complexity of LGBTQ microaggressions. This proposed model includes the following elements: hegemonic influences, intersectional complexities, perpetration, interpersonal and environmental contexts, and responses.

Heterotypic trans-interaction of LI- and E-cadherin and their localization in plasmalemmal microdomains.

Cadherins are calcium-dependent adhesion molecules important for tissue morphogenesis and integrity. LI-cadherin and E-cadherin are the two prominent cadherins in intestinal epithelial cells. Whereas LI-cadherin belongs to the subfamily of 7D (seven-domain)-cadherins defined by their seven extracellular cadherin repeats and short intracellular domain, E-cadherin is the prototype of classical cadherins with five extracellular domains and a highly conserved cytoplasmic part that interacts with catenins and thereby modulates the organization of the cytoskeleton.

Imaging and force spectroscopy on desmoglein 1 using atomic force microscopy reveal multivalent Ca(2+)-dependent, low-affinity trans-interaction.

Desmoglein 1 is a desmosomal member of the cadherin family expressed in stratified epithelia. Desmoglein 1 is the target adhesion molecule of severe blistering skin diseases such as pemphigus or bullous impetigo. However, despite this enormous pathological relevance, the molecular binding properties of desmoglein 1 are largely unknown.

Ischemia-induced association of the stress protein alpha B-crystallin with I-band portion of cardiac titin.

During ischemia the cardiac stress protein, alpha B-crystallin, was shown by immunoelectron microscopy to translocate to the N(2)-line area of myofibrillar I-bands of rat cardiomyocytes where alpha B-crystallin resisted extraction with 1 m NaSCN and 2 m urea as did titin. Actin became completely extracted under these conditions, indicating association of alpha B-crystallin with titin the only remaining non-actin cytoskeletal component of I-bands outside Z-disks. Titin, extracted from ischemic pig myocardium, was shown to copurify with alpha B-crystallin.

[Expert assessment of medical malpractice].

Conciliation boards are advisory commissions of the medical societies. They deal with clarification of extrajudicial patient claims based on factual or putative treatment mistakes. In perhaps 90% of the cases, an extrajudicial solution is possible, whereby the federal average for recognition is 30%.