Publications by authors named "R Konishi"
An 82-year-old woman with a history of myocardial infarction presented with worsening effort angina. Coronary angiography (CAG) revealed 75% stenosis in the proximal left anterior descending artery (LAD), with intravascular ultrasound (IVUS) identifying a severe calcified nodule near a previously implanted drug-eluting stent. The lesion was treated with intravascular lithotripsy (IVL) and a drug-coated balloon (DCB), avoiding left main crossover stenting.
View Article and Find Full Text PDFThis study aimed to classify subgroups of healthy young adults based on foot stiffness and related kinetic parameters during gait, as well as to analyze intra-foot sagittal kinematics within each subgroup. Data were collected from 25 males and 24 females using a 3D motion capture system, which measured the rearfoot, midfoot, and forefoot segments. Cluster analysis identified three subgroups based on the following variables: the truss coefficient, windlass coefficient, forward component of ground reaction force (F-GRF), and ankle plantar flexion power.
View Article and Find Full Text PDFArticle Synopsis
- Short-chain esters like isobutyl and isoamyl acetate are valuable in industries such as flavors, fragrances, solvents, and biofuels.
- The research focused on using the yeast Yarrowia lipolytica to biosynthesize these esters by introducing specific alcohols and enhancing the production with genetic modifications of the yeast.
- By optimizing conditions and increasing acetyl-CoA levels, the study achieved significant yields of isoamyl acetate, showcasing the potential of Y. lipolytica in the effective production of various acetate esters.
Article Synopsis
- Researchers used a 5' single-cell RNA sequencing method to identify where enhancer RNAs and other RNA types start in human CD4 T cells, uncovering variations in cell types and their development.
- By combining these RNA datasets with single-cell chromatin profiles, they found that unique active enhancers and their RNA production are specific to certain cell types and are linked to disease risk.
- The study created a detailed atlas of these enhancers that helps to understand how genetic variations are related to various immune-mediated diseases.