Cytologic and Molecular Assessment of Isthmus Thyroid Nodules and Carcinomas.

Isthmic thyroid nodules are more likely to be malignant and isthmic differentiated thyroid cancer demonstrates less favorable behavior compared with lobar locations. The goal of this study was to assess molecular differences of thyroid nodules and carcinomas from the isthmus relative to the lobes. The Afirma thyroid nodule database ( = 177,227) was assessed for cytologic and molecular differences between isthmus and lobar nodules in this observational cohort study.

Analytical Validation of a Telomerase Reverse Transcriptase (TERT) Promoter Mutation Assay.

Context: Telomerase reverse transcriptase (TERT) promoter-mutated thyroid cancers are associated with a decreased rate of disease-free and disease-specific survival. High-quality analytical validation of a diagnostic test promotes confidence in the results that inform clinical decision-making.

Objective: This work aimed to demonstrate the analytical validation of the Afirma TERT promoter mutation assay.

Histopathology of telomerase reverse transcriptase promoter () mutated indeterminate thyroid nodules.

Objective: The objective of this study was to analyze the risk of malignancy and the histopathology of telomerase reverse transcriptase promoter mutated cytologically indeterminate thyroid nodules (ITN).

Methods: A PUBMED search of molecularly tested ITN was conducted and data on mutated ITN with histopathology correlation were extracted.

Results: Twenty-six manuscripts (published between 2014 and 2022) reported on 77 mutated ITN.

Effects of orbital decompression on duction, cyclotorsion and diplopia.

Background: Orbital decompression is commonly performed to correct proptosis in patients with Graves' orbitopathy (GO). In literature, the incidence of new-onset constant diplopia after orbital decompression varies. Few studies have evaluated changes in duction and cyclodeviation after orbital decompression.

[Watery eyes: diagnostic and therapeutic considerations].

Tear complaints can arise from either an increased tear production or from a disturbed tear drainage. Increased tear production from the lacrimal gland is a neuroregulated response to a dried out or irritated ocular surface. Dryness often results from a reduced quality of the tear film, but can also be caused by eyelid malposition with increased globe exposure.