Publications by authors named "R Klingenberg"
Objectives: To assess the association between the intensity of statin therapy and the level of physical activity in patients 1 year after an acute coronary syndrome (ACS).
Design: Prospective cohort study from the Special Program University Medicine-Acute Coronary Syndromes.
Setting: Four university hospital centres in Switzerland.
Article Synopsis
- The study assessed eligibility for marine omega-3 fatty acid eicosapentaenoic acid (EPA) supplementation in patients with acute coronary syndromes (ACS) in a Swiss cohort, as recommended by 2019 European Society of Cardiology guidelines.
- Out of 2643 patients, 32% were eligible for EPA supplementation one year post-ACS, with higher eligibility rates found in younger individuals, smokers, diabetics, hypertensive patients, and the obese.
- The research indicates that statins and other lipid-lowering therapies could reduce the percentage of these patients eligible for omega-3 supplementation, suggesting a need to address residual cardiovascular risk in those with hypertriglyceridemia.
Mini-Review: Immunogenic epitopes in apolipoprotein B-100 for atheroprotective immunization.
Front Cardiovasc Med
August 2024
Here, we provide a concise overview of recent developments in the identification of immunogenic epitopes in human apolipoprotein B-100 for immunization against atherosclerotic cardiovascular disease. Major steps forward toward a clinical application of vaccines include the design of humanized mouse models, tetramer-based identification of antigen-specific T cells, and novel analysis tools, such as single-cell RNA sequencing and cytometry by time of flight, to assess temporal and spatial changes in immune cells in atherosclerotic cardiovascular disease.
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- Acute coronary syndromes (ACS) presenting on rest days, such as weekends or holidays, are linked to higher mortality rates in patients experiencing acute decompensated heart failure (ADHF).
- A study analyzed data from the SPUM-ACS Cohort, with 4787 ACS patients, revealing that those with ADHF had a significantly higher one-year mortality rate (34.6%) when treated on rest days compared to workdays (17.4%).
- The findings suggest that the time of presentation impacts long-term survival, emphasizing the need for further research into this "rest day effect" on patient outcomes.
Article Synopsis
- The study aimed to assess the risk of alcohol consumption after patients experienced acute coronary syndromes (ACS) among 6,557 participants over a 12-month period.
- Researchers tracked weekly alcohol consumption and defined binge drinking as consuming six or more alcoholic units on one occasion, while monitoring for major cardiovascular events (MACE).
- Results indicated that binge drinking, even at low frequency, was linked to a higher risk of MACE, contrasting with heavy and light alcohol consumption levels, which showed no significant increase in risk compared to abstinence.