Publications by authors named "R Klaus"
Congenital anomalies of the kidney and urinary tract (CAKUT) are the leading cause of kidney failure in children and adolescents. CAKUT describes a wide spectrum of structural disorders with a prenatal origin. The etiology of CAKUT is multifactorial, including environmental, nongenetic, and genetic causes that impact kidney development as well as upper and lower urinary tract development.
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- Anti-GBM disease is a rare and serious condition characterized by the body producing antibodies that attack a specific type of collagen in the kidneys, leading to quick kidney failure if not treated.
- Current treatment guidelines recommend using plasma exchanges and drugs like steroids and cyclophosphamide, but cyclophosphamide can have severe side effects, prompting the search for alternatives like rituximab and mycophenolate mofetil.
- A study analyzing five adolescent patients treated with rituximab and mycophenolate mofetil found promising results, with 80% showing preserved or improved kidney function after treatment, suggesting these alternatives may be less toxic and effective.
Urinary tract obstruction during renal development leads to inflammation, leukocyte infiltration, tubular cell death, and interstitial fibrosis. Interleukin-10 (IL-10) is an anti-inflammatory cytokine, produced mainly by monocytes/macrophages and regulatory T-cells. IL-10 inhibits innate and adaptive immune responses.
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- * A total of 1454 urinary proteins were identified, with clean catch samples showing a slightly higher number and intensity of proteins compared to urine bags, but the difference was not statistically significant.
- * Results revealed a 29% difference in protein detection between collection methods, but a strong correlation (0.81) indicates that biological factors are more important than the collection method itself in determining urinary proteomics.