Publications by authors named "R Killick"
Synaptogenesis involves the transformation of dendritic filopodial contacts into stable connections with the exact apposition of synaptic components. Signalling triggered by Wnt/β-catenin and calcium has been postulated to aid this process. However, it is unclear how such a signalling process orchestrates synapse formation to organise the spatial arrangement of synapses along dendrites.
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- Short sleep duration is linked to serious health risks, including heart disease and diabetes, based on epidemiologic findings.
- Experimental studies aim to understand how restricted sleep contributes to these health issues and identify underlying mechanisms.
- The review also explores whether increasing sleep can reverse these negative health effects and discusses the potential for implementing sleep improvement strategies in public health initiatives.
The problem of health and care of people is being revolutionized. An important component of that revolution is disease prevention and health improvement from home. A natural approach to the health problem is monitoring changes in people's behavior or activities.
View Article and Find Full Text PDFBackground: Oral cavity squamous cell carcinomas (OCSCCs) are relatively common in multiple non-human primate species but are poorly documented in Goeldi's monkeys.
Methods: Four Goeldi's monkeys with OCSCC, from three zoological collections, underwent necropsy with cytology, histopathology, immunohistochemistry, and pan-herpesvirus PCR analysis.
Results: All animals were euthanised and exhibited poor-to-emaciated body condition.
Article Synopsis
- - The systematic review examines how type 2 diabetes mellitus (T2DM) raises the risk of late-onset Alzheimer's dementia (LOAD) by analyzing common metabolic mechanisms that connect the two conditions, including insulin signaling and inflammation.
- - It consolidates findings from both human and animal studies, evaluating 923 publications for pathophysiological mechanisms and 357 for genomic associations and epigenetic modifications, ultimately identifying 138 gene loci linked to risk factors.
- - The gathered evidence emphasizes the interplay between brain insulin resistance, neuroinflammation, and metabolic issues in T2DM and LOAD, suggesting pathways for future longitudinal research on their interconnected risks.