Publications by authors named "R Khurshid"
Age is a known determinant of reproductive health and fertility in both genders. The present work aims to assess the reproductive hormone profile of a middle-aged and elderly man. For this descriptive cross-sectional study, healthy male subjects (n=77) were recruited from the valley.
View Article and Find Full Text PDFSTK17A is a novel uncharacterized member of the death-associated protein family of serine and threonine kinases. Overexpression of STK17A is observed in many cancers. We identified a lead compound that is based on a quinazoline core.
View Article and Find Full Text PDFCOVID-19 remains a severe public health threat despite the WHO declaring an end to the public health emergency in May 2023. Continual development of SARS-CoV-2 variants with resistance to vaccine-induced or natural immunity necessitates constant vigilance as well as new vaccines and therapeutics. Targeted protein degradation (TPD) remains relatively untapped in antiviral drug discovery and holds the promise of attenuating viral resistance development.
View Article and Find Full Text PDFArticle Synopsis
- Polycystic ovary syndrome (PCOS) diagnosis commonly involves indicators such as irregular periods, high androgen levels, and ovarian structure; however, the impact of frequent periods (polymenorrhoea) and partial PCOS cases remains underexplored.
- In a study with over 9,600 women, those diagnosed with PCOS, especially with hyperandrogenism or oligomenorrhoea, displayed higher body mass index (BMI), elevated blood glucose, and lipid levels compared to healthy women, while insulin resistance levels were notably higher across the board.
- The polymenorrhoea subgroup showed lower BMI and testosterone levels but shared similar metabolic characteristics with women experiencing oligomenorrhoea