Renal and hepatic tolerance of nonionic and ionic contrast media in intravenous digital subtraction angiography.

The liver and kidney tolerance of iopromide 370 in comparison to that of sodium meglumine diatrizoate 370 or iopamidol 370 in doses of 2 ml/kg body weight was examined in two controlled double-blind studies with intravenous digital subtraction angiography on the basis of enzyme assays in serum and urine. In patients with normal kidney function no changes were observed in the levels of the liver enzymes GPT, GOT, and gamma glutamyl transpeptidase (GGT) serum up to 72 hours after injection of iopromide or sodium meglumine diatrizoate. Among the kidney-specific enzymes, the excretion of GGT in urine increased after injection of iopromide and iopamidol.

Iopromide dosage and urographic image quality: is there an optimal dose?

The influence of increasing doses of contrast medium (CM; 0.75, 1.0, 1.

Renal excretion of iopromide and iopamidol after intravenous administration in digital subtraction angiography.

After injection of iopromide or iopamidol into a central vein in 40 patients ages 57 +/- 14 years and 57 +/- 11 years, respectively, with normal renal function, iodine concentration and total iodine excretion were determined in pooled urine over 0 to 2 hours and 2 to 24 hours after injection. Iopromide excretion of 46.4 +/- 9.

Comparative study between iohexol and iopromide for aortofemoral arteriography.

A double-blind clinical trial was performed on 50 patients in order to compare omnipague (iohexol) and Ultravist-300 (iopromide) for peripheral arteriography. Both contrast media were well tolerated, but there was less body heat and pain in the Ultravist group. There were no idiosyncratic reactions or significant changes in blood pressure before and after the injection.

[Modification of the image quality of i.v. DSA by the iodine concentration of the contrast medium].

In randomised, double-blind clinical trials it could be demonstrated that in iv. DSA the image quality is reduced if the iodine concentration of the nonionic contrast medium iopromide is higher than 370 mgI/ml, the total amount of injected iodine being constant. This effect is due to the increased viscosity of contrast media containing a high iodine concentration per ml solution.