Publications by authors named "R Kettritz"
Background And Hypothesis: Donor-derived cell-free DNA (dd-cfDNA) shows good diagnostic performance for the detection of antibody-mediated rejection (AMR) in kidney transplant recipients (KTR). However, the clinical benefits of dd-cfDNA monitoring need to be established. Early diagnosis of AMR at potentially reversible stages may be increasingly important due to emerging treatment options for AMR.
View Article and Find Full Text PDFArticle Synopsis
- Neutrophils use β-integrins to migrate to inflammation sites with low oxygen and high cytokine levels, and inhibiting prolyl hydroxylase domain-containing enzymes (PHDs) is thought to activate the HIF pathway in these cells.
- In experiments using PHD inhibitors or hypoxic conditions, researchers found that HIF1α protein accumulation occurs in adherent neutrophils, but not in suspended ones, highlighting the necessity of β-integrins for this process.
- The study revealed that β-integrins not only promote HIF1α mRNA translation through key factors, but also that activating HIF1α can delay neutrophil apoptosis, suggesting a vital role for this pathway in neutrophil survival
An uncontrolled activity of neutrophil serine proteases (NSPs) contributes to inflammatory diseases. Cathepsin C (CatC) is known to activate NSPs during neutrophilic differentiation and represents a promising pharmacological target in NSP-mediated diseases. In humans, Papillon-Lefèvre syndrome (PLS) patients have mutations in theirCTSC gene, resulting in the complete absence of CatC activity.
View Article and Find Full Text PDFOsmotic gradients over cell membranes lead to water movement into or out of cells. An intact osmoregulation prevents osmotic gradients, thereby protecting cells from swelling or shrinking. Na is the major cation in the extracellular fluid (ECF) and the major determinant of the osmolarity in the ECF, including plasma.
View Article and Find Full Text PDF