Publications by authors named "R Kesselring"
Background/objectives: Colorectal cancer (CRC) with hepatic (CRLM) and pulmonary metastases (CRLU) presents a significant clinical challenge, leading to poor prognosis. Surgical resection of these metastases remains controversial because of limited evidence supporting its long-term benefits. To evaluate the impact of surgical resection of both hepatic and pulmonary metastases on long-term survival in patients with multivisceral metastatic colorectal cancer, this retrospective cohort study included 192 patients with UICC stage IV CRC treated at a high-volume academic center.
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- The study investigates how partial hepatectomy (pHx), a common surgical procedure for colorectal liver metastasis in Stage IV colorectal cancer (CRC), influences tumor progression at a molecular level using a mouse model.
- Mice that underwent pHx showed significant liver growth and a higher metastatic load compared to control mice, indicating that pHx may enhance the spread of CRC to the liver rather than simply removing existing tumors.
- The findings suggest that pHx triggers inflammatory responses and tissue changes in the liver, creating an environment that promotes the establishment of new metastatic tumors, highlighting the need for a better understanding of post-surgery cancer dynamics.
Metastasized colorectal cancer (CRC) is associated with a poor prognosis and rapid disease progression. Besides hepatic metastasis, peritoneal carcinomatosis is the major cause of death in Union for International Cancer Control (UICC) stage IV CRC patients. Insights into differential site-specific reconstitution of tumor cells and the corresponding tumor microenvironment are still missing.
View Article and Find Full Text PDFTherapeutic options for metastatic colorectal cancer (mCRC) are very limited, and the prognosis using combination therapy with a chemotherapeutic drug and a targeted agent, e.g., epidermal growth factor receptor or tyrosine kinase, remains poor.
View Article and Find Full Text PDFUnlabelled: In colorectal cancers, the tumor microenvironment plays a key role in prognosis and therapy efficacy. Patient-derived tumor organoids (PDTO) show enormous potential for preclinical testing; however, cultured tumor cells lose important characteristics, including the consensus molecular subtypes (CMS). To better reflect the cellular heterogeneity, we established the colorectal cancer organoid-stroma biobank of matched PDTOs and cancer-associated fibroblasts (CAF) from 30 patients.
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