Publications by authors named "R Kerestes"
Twin studies have found gross cerebellar volume to be highly heritable. However, whether fine-grained regional volumes within the cerebellum are similarly heritable is still being determined. Anatomical MRI scans from two independent datasets (QTIM: Queensland Twin IMaging, N = 798, mean age 22.
View Article and Find Full Text PDFObjective: The intricate neuroanatomical structure of the cerebellum is of longstanding interest in epilepsy, but has been poorly characterized within the current corticocentric models of this disease. We quantified cross-sectional regional cerebellar lobule volumes using structural magnetic resonance imaging in 1602 adults with epilepsy and 1022 healthy controls across 22 sites from the global ENIGMA-Epilepsy working group.
Methods: A state-of-the-art deep learning-based approach was employed that parcellates the cerebellum into 28 neuroanatomical subregions.
Article Synopsis
- The study explores the lesser-known role of the cerebellum in PTSD by analyzing cerebellar volume differences in a large sample of 4,215 adults, with 1,642 diagnosed with PTSD and 2,573 as healthy controls.
- Using advanced deep-learning techniques, researchers assessed the total cerebellum volume and 28 subregions, revealing significant reductions in both gray and white matter in individuals with PTSD, especially in specific posterior lobe and vermis areas.
- The results suggest that changes in cerebellar structure are linked to cognitive and emotional dysfunctions in PTSD, highlighting the cerebellum's importance beyond its traditional role in motor control.
Importance: Traumatic brain injury (TBI) is known to cause widespread neural disruption in the cerebrum. However, less is known about the association of TBI with cerebellar structure and how such changes may alter executive functioning.
Objective: To investigate alterations in subregional cerebellum volume and cerebral white matter microstructure after pediatric TBI and examine subsequent changes in executive function.
Background: Increasing evidence points to a pathophysiological role for the cerebellum in Parkinson's disease (PD). However, regional cerebellar changes associated with motor and non-motor functioning remain to be elucidated.
Objective: To quantify cross-sectional regional cerebellar lobule volumes using three dimensional T1-weighted anatomical brain magnetic resonance imaging from the global ENIGMA-PD working group.