Histological Injury to Rat Brain, Liver, and Kidneys by Gold Nanoparticles is Dose-Dependent.

Gold nanoparticles (GNPs) possess various interesting plasmonic properties that can provide a variety of diagnostic and therapeutic functionalities for biomedical applications. Compared to other inorganic metal nanoparticles (NPs), GNPs are less toxic and more biocompatible. However, the toxicity of gold nanoparticles on humans can be significant due to the size effect.

Measured volumes using segmented tissue probability data obtained using statistical parametric mapping 12 were not influenced by the contrasts of analyzed images.

The aim of this study was to evaluate changes in measured volumes using Statistical Parametric Mapping (SPM) 12 caused by contrast changes in magnetic resonance (MR) image. Twenty-one healthy subjects participated in the study. From all subjects, 3D T1-weighted images (T1WIs) were obtained using a 3T scanner.

Bilateral effects of hospital patient-safety procedures on nurses' job satisfaction.

Aim: The aim of this study was to examine how hospital patient-safety procedures affect the job satisfaction of hospital nurses. Additionally, we investigated the association between perceived autonomy and hospital patient-safety procedures and job satisfaction.

Background: Recently, measures for patient safety have been recognized as an essential requirement in hospitals.

Visualization of the molecular dynamics of lipopolysaccharide on the plasma membrane of murine macrophages by total internal reflection fluorescence microscopy.

The molecular action of Alexa 594-labeled lipopolysaccharide (LPS) from Escherichia coli was examined on living peritoneal macrophages of C57BL/6 mice by total internal reflection fluorescence microscope (TIRFM), and the molecular kinetics of LPS was analyzed. TIRFM visualization of the action of fluorescence-labeled LPS revealed an increase in the mean fluorescence intensity of LPS on the plasma membrane of wild type macrophages at 60 min after administration, indicating the oligomerization of LPS after binding to the macrophages. Additionally, a time-dependent sharp decrease in the mean diffusion coefficient of LPS was observed.

[Pathophysiology of sepsis--will the basic research contribute to the improvement of outcome in clinical sepsis?].

In this decade, the molecular mechanism of sepsis has been strikingly clarified. Especially, the identification of toll-like receptors as the pivotal molecules for the recognition of the stimulation of the inflammatory products of microorganisms has contributed to the elucidation of intracellular signaling pathways which result in severe systemic inflammatory response in sepsis. The production and release of a variety of pro-inflammatory mediators have been found to be associated with severe systemic inflammation and multiple organ dysfunction syndrome (MODS).