Publications by authors named "R Kanthan"
Background: In this large population-based cohort study, we examined the prognostic significance of various clinical, pathological, and contextual variables for their correlation with survival in elderly patients with stage III colon cancer.
Methods: Patients aged ≥ 70 years with stage III colon cancer, diagnosed in Saskatchewan during 2012-2018, were evaluated. A Cox proportional multivariate survival analysis was performed to determine factors correlated with overall survival (OS) and disease-free survival.
Article Synopsis
- Gallbladder cancer (GBC) is rare, and a study analyzed its outcomes in Saskatchewan, Canada, from 2000 to 2019, examining factors like geography and clinical details.
- The study found that most patients were diagnosed at an advanced stage, with 64% having stage IV disease, and many did not receive referrals to specialized cancer treatment centers.
- Survival rates were worse for older patients, those with higher disease stages, no surgical intervention, and a high neutrophil-to-lymphocyte ratio, highlighting the need for earlier diagnosis and better referral practices.
Estrogen/Progesterone Receptor Loss, CTNNB1 and KRAS Mutations Are Associated With Local Recurrence or Distant Metastasis in Low-Grade Endometrial Endometrioid Carcinoma.
Appl Immunohistochem Mol Morphol
March 2023
A subset of endometrial endometrioid carcinomas (EECs) with low-grade histology recur with poor outcomes. Published evidence suggests that poor outcomes may be associated with loss of expression of ER-alpha (ER-α) as well as with β-Catenin-1 ( CTNNB1 ) and Kirsten rat sarcoma viral oncogene homolog ( KRAS ) mutations. This study reports on institutional experience with the incidence of recurrence in low-grade EEC and their association with CTNNB1 and KRAS mutations as well as estrogen/progesterone receptor (ER/PR) expression.
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- The study focused on small intestine adenocarcinoma outcomes in Saskatchewan, Canada, analyzing data from 112 patients diagnosed between 2008 and 2017.
- Most patients were older (median age 73) and had advanced-stage disease, with significant survival differences based on cancer stage; for instance, stage one had a median overall survival of 59 months compared to just 3 months for stage four.
- Factors like advanced disease stage, poor performance status, lack of surgical intervention, and a high neutrophil:lymphocyte ratio were linked to worse survival outcomes.