Severe neutropenia due to naproxen therapy in rheumatoid arthritis: a case report and review of literature.

Rheumatoid arthritis is a chronic inflammatory disease that primarily affects the joints and is often treated with non-steroidal anti-inflammatory drugs (NSAIDs) on demand and disease-modifying antirheumatic drugs (DMARDs), with a relatively low risk of side effects. Although an infrequent side effect, neutropenia has been described as a sequel of NSAIDs. We report a case of neutropenia proven (by rechallenge) to be due to naproxen therapy.

[Hyponatremia caused by thiazide diuretics: be aware of drug combinations which enhance this effect].

In 3 patients, two women aged 88 and 82 and a man aged 76, the consciousness became disrupted due to a severe hyponatraemia, after a thiazide diuretic had been combined with another drug without laboratory control. After a change in medication, the laboratory values and the patients' conditions normalised. Severe hyponatraemia is a well known but rare complication of thiazide therapy.