Publications by authors named "R Kalaehne"
This hospital-based cross-sectional study aimed to screen newborns for sickle cell anemia immediately after birth and validate dried blood spot (DBS) samples against conventional venous blood samples (CBS) for hemoglobin variant analysis by HPLC. Among 751 newborns, 2.93% were found to have sickle cell trait.
View Article and Find Full Text PDFEndophytes from medicinal plants are potential biocontrol agents against Fusarium oxysporum f. sp. cubense (Foc), which is the causative fungus of banana wilt disease.
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- In Indian states, many public health programs are led by clinicians lacking formal leadership training, prompting Uttar Pradesh to launch a Public Health Management and Leadership program for mid-career medical officers to enhance their administrative skills.
- The training included essential skills such as leadership, communication, and problem-solving through in-person sessions and hands-on projects, with participant feedback measured via Kirkpatrick's model and statistical analyses showing notable but moderate improvements in learning outcomes.
- Despite high satisfaction with the program, participants struggled to apply management concepts due to contextual limitations and barriers like resource constraints and gender stereotypes, suggesting a need for additional training in finance and human resources.
The P53 protein, a cancer-associated transcriptional factor and tumor suppressor, houses a Zn ion in its DNA-binding domain (DBD), essential for sequence-specific DNA binding. However, common mutations at position 273, specifically from Arginine to Histidine and Cysteine, lead to a loss of function as a tumor suppressor, also called DNA contact mutations. The mutant (MT) P53 structure cannot stabilize DNA due to inadequate interaction.
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