Real-world effectiveness of mepolizumab in Japanese asthma patients with diverse backgrounds: Improvements in rhinosinusitis imaging (J-Real-Mepo).

Background: Although randomized controlled trials (RCT) have demonstrated the efficacy of mepolizumab for asthma, they have excluded certain patient subgroups. To bridge the gap between RCT and real-world practice, the effectiveness of mepolizumab in a diverse population, including those potentially excluded from RCT, was assessed. Its effects on imaging findings and symptoms of chronic rhinosinusitis (CRS) with asthma were also assessed.

[A CASE OF EOSINOPHILIC GRANULOMATOSIS WITH POLYANGIITIS WITH RHINOSINUSITIS CONTROLLED WITH ENDOSCOPIC SINUS SURGERY].

Eosinophilic granulomatosis with polyangiitis (EGPA) is a disease with marked elevation of blood eosinophil associated with various symptoms in the respiratory tract, gastrointestinal tract, peripheral nerves, and skin due to systemic vasculitis. Here, we report a case of EGPA in which rhinosinusitis was treated with endoscopic sinus surgery (ESS) with good results. A 49-year-old man who developed bronchial asthma at age 48 was diagnosed with EGPA in our hospital.

A Case of Coexistent Fungal Rhinosinusitis and Actinomycosis Caused by Gutta-Percha Points Extruded Into the Maxillary Sinus.

Dental materials can stray into the maxillary sinus, causing maxillary sinusitis. We present a case of coexistent fungal rhinosinusitis and actinomycosis caused by gutta-percha points, a core-filling material used for root canal treatment. A 56-year-old man who had undergone root canal treatment with gutta-percha points visited our oral surgery department with complaints of purulent nasal discharge lasting one month.

A Case of Fungal Maxillary Sinusitis Extending to the Contralateral Side Through the Nasal Septum.

Fungal rhinosinusitis (FRS) presents as various phenotypes ranging from asymptomatic colonization to life-threatening infections. Here, we report an atypical case of FRS of the left maxillary sinus that extended to the contralateral maxillary sinus through the nasal septum. An 80-year-old woman with a history of osteoporosis was referred to our hospital for further management of headaches and chronic rhinosinusitis.