Publications by authors named "R Kafesjian"

It has been postulated that, in theory, stentless bioprosthetic heart valves provide improved hemodynamics and durability over their stented counterparts. A number of glutaraldehyde modified porcine stentless valves are currently either on the market or in clinical trials. Polyepoxy compound as an alternative cross-linking reagent to glutaraldehyde for bioprostheses has been reported to mitigate calcification.

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An in vitro study was designed to evaluate the effect of structural compliance on cavitation threshold measurements of mechanical heart valves. Using a dual channel high speed video image analysis method, the experiment was carried out in a pulse duplicator under a single, simulated physiologic condition. Each valve was mounted on a compliance adjustable fixture.

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A summary of the observations of cavitation-related damage is presented for over a hundred mechanical heart valves (MHV) containing pyrolytic carbon components. Valves were obtained from several types of simulators, animal studies and clinical explantations, and were primarily of the bileaflet type. Damage on these valves was documented as to location, type, and severity.

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Article Synopsis
  • A study was conducted on 15 bileaflet mechanical heart valves at the Helmholtz Institute in Germany, comparing the modified and earlier versions of Edwards-Duromedics valves with St. Jude Medical valves under two pressure curve conditions.
  • The valves were tested across nine conditions, filmed using two systems: a strobe light system and a high-speed video recording system for detailed analysis.
  • Data from both recording systems were independently analyzed to verify consistency and assess the reliability of methods for detecting cavitation thresholds.
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