[The chaos theory in parasitology].

Fundamental ideas of the chaotic non-linear dynamical systems and their application in parasitology (e.g. Cephalomyvia populations, Trichomronas vaginalis invasions, Homo-Plasmodium systems) are discussed.

The effect of Ascaris trypsin inhibitor on proteolytic activity of lungs and kidneys of guinea pig with larval ascariosis and after ascarid homogenate administration.

Trypsin inhibitor, isolated from Ascaris suum tegument reduces in vitro proteolytic activity (pH 7) of lungs and kidneys post-nuclear fractions of guinea pigs with larval ascariosis, pigs after subcutaneous ascarid homogenate administration as well as the activity in control groups. The comparative analysis of effect curves of trypsin inhibitor on the organ proteases revealed stronger reduction of the activity of post-nuclear lung proteases in ascariosis and of kidneys proteases after the injection of Ascaris homogenate than the inhibition of the fractions activity from respective control groups.

Preliminary evaluation of maternotoxic effect of Ascaris alpha-chymotrypsin inhibitor in mice.

Administration intraperitoneally of the Ascaris alpha-chymotrypsin inhibitor (40-300 mg/kg/day) at a late stage of organogenesis (8-12 days of gestation) disturbed course of mouse pregnancy. The low doses of alpha-chymotrypsin inhibitor (40-80 mg/kg/day) significantly decreased the number of live fetuses per litter, increased the number of fetal resorptions. The symptoms of maternal toxicity that occurred after administration of the highest doses of the inhibitor (80-300 mg/kg/day) to pregnant mice included: decreased body weight gain as compared to control, vaginal hemorrhage, intrauterine resorption of litters, abortions, altered behaviour of animals immediately after injection and death.

[Teratogenic action of alpha-chymotrypsin inhibitor of Ascaris lumbricoides in mice].

During investigations of biological activity of proteolysis inhibitors from Ascaris lumbricoides, teratogenic action of alfa-chymotrypsin inhibitor (ICH) was evaluated. The inhibitor was obtained by a method of Roli and Pudles and was applied parenterally at 8-12 day of pregnancy to BALB/c mice in doses of 20-80 mg/kg of mice per 24 hours. Control groups received respectively 1 cm3 of 0.

[The effect of Ascaris lumbricoides suis and its trypsin inhibitor on the chick embryo].

It has been found that tegument homogenate of Ascaris lumbricoides suis and also trypsin inhibitor isolated from it induce the Leghorn chick embryos mortality when injected into their yolk sac on 4th, 8th or 13th day of incubation. The trypsin inhibitor is one of important components of Ascaris homogenate causing mortality. There is linear interrelationship between the logarithm of dose of homogenate or trypsin inhibitor and the mortality of chickens in %.