Publications by authors named "R Kaderli"
Article Synopsis
- Resecting a large goiter that extends into the chest area is complex, and traditional surgical methods like sternotomy can lead to higher complications (up to 30% morbidity rates).
- The video outlines a promising alternative technique called thoracoscopic-assisted transcervical resection, which minimizes the need for more invasive procedures while maintaining safety by monitoring critical nerves during surgery.
- A case study of an 84-year-old man with thyroid cancer illustrates that this method can lead to successful outcomes with fewer complications and a shorter hospital stay, demonstrating its potential as a preferred approach.
Objectives: Preoperative and intraoperative diagnostic tools influence the surgical management of primary hyperparathyroidism (PHPT), whereby their performance of classification varies considerably for the two common causes of PHPT: solitary adenomas and multiglandular disease. A consensus on the use of such diagnostic tools for optimal perioperative management of all PHPT patients has not been reached.
Design: A decision tree model was constructed to estimate and compare the clinical outcomes and the cost-effectiveness of preoperative imaging modalities and intraoperative parathyroid hormone (ioPTH) monitoring criteria in a 21-year time horizon with a 3% discount rate.
The calcium sensing receptor (CaSR) is a ubiquitously expressed G-protein coupled receptor (GPCR) that regulates extracellular calcium signals the parathyroid glands. CaSR has recently also been implicated in noncalcitropic pathophysiologies like asthma, gut inflammation, and cancer. To date, molecular tools that enable the bioimaging of CaSR in tissues are lacking.
View Article and Find Full Text PDFPrimary hyperparathyroidism with parathyroid tumors is a typical manifestation of Multiple Endocrine Neoplasia Type 1 (MEN1) and is historically termed "primary hyperplasia". Whether these tumors represent a multi-glandular clonal disease or hyperplasia has not been robustly proven so far. Loss of Menin protein expression is associated with inactivation of both alleles and a good surrogate for a MEN1 gene mutation.
View Article and Find Full Text PDF