Publications by authors named "R K Zhu"
Atractylenolide I (ATL-I) can interfere with Colorectal cancer (CRC) cell proliferation by changing apoptosis, glucose metabolism and other behaviors, making it an effective drug for inhibiting CRC tumor growth. In this paper, we investigated the interactions between ATL-I and Keratin 7 (KRT7), a CRC-specific marker, to determine the potential pathways by which ATL-I inhibits CRC development. The KRT7 expression level in CRC was predicted online using the GEPIA website and then validated.
View Article and Find Full Text PDFBackground: Ferroptosis and immune responses are critical pathological events in spinal cord injury (SCI), whereas relative molecular and cellular mechanisms remain unclear.
Methods: Micro-array datasets (GSE45006, GSE69334), RNA sequencing (RNA-seq) dataset (GSE151371), spatial transcriptome datasets (GSE214349, GSE184369), and single cell RNA sequencing (scRNA-seq) datasets (GSE162610, GSE226286) were available from the Gene Expression Omnibus (GEO) database. Through weighted gene co-expression network analysis and differential expression analysis in GSE45006, we identified differentially expressed time- and immune-related genes (DETIRGs) associated with chronic SCI and differentially expressed ferroptosis- and immune-related genes (DEFIRGs), which were validated in GSE151371.
Article Synopsis
- Pulmonary artery hypertension (PAH) exhibits a metabolic shift towards aerobic glycolysis, resembling cancer metabolism, and involves the role of NSD2, though its exact function is not fully understood.
- Increased expression of FOLR1 in PAH tissues was linked to NSD2, and silencing either NSD2 or FOLR1 inhibited cell proliferation and the progression of PAH.
- The study found that NSD2 influences the activity of FOLR1, affecting glycolytic gene expression and metabolic processes in pulmonary artery endothelial cells, suggesting a potential pathway for therapeutic intervention in PAH.
This study aims to elucidate the target and mechanism of baicalin, a clinically utilized drug, in the treatment of neuroinflammatory diseases. Neuroinflammation, characterized by the activation of glial cells and the release of various pro-inflammatory cytokines, plays a critical role in the pathogenesis of various diseases, including spinal cord injury (SCI). The remission of such diseases is significantly dependent on the improvement of inflammatory microenvironment.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on creating effective and affordable electrocatalysts for water electrolysis, vital for improving technology in this area.
- The authors developed a novel catalyst by anchoring carbonyl iron powder in nickel foam, leading to enhanced surface area and efficient ion movement.
- The catalyst exhibits high activity due to a dynamic interaction between different nickel and iron phases, significantly boosting its performance in the oxygen evolution reaction.