Does new research address persistent questions since the publication of the CDC's 2018 pediatric mTBI guideline.

Background And Objective: Due to the potential debilitating sequelae following pediatric mTBI, the CDC published the Guideline on the Diagnosis and Management of mTBI Among Children in 2018. However, the guideline identified several key gaps in our clinical knowledge to support several clinical recommendations. The objective of this review is to evaluate if subsequent research has addressed these gaps in clinical practice recommendations.

Oleuropein: a viable therapeutic option for malaria and cancer.

Oleuropein (OLP) holds promise as a therapeutic candidate for both Plasmodium falciparum infection and cancer. It modulates the phosphoinositide 3-kinase (PI3K)-Akt1 signaling pathway to regulate inflammation and restore immune homeostasis. Moreover, it influences the cell death/autophagy axis, along with increasing the antimalarial efficacy of artemisinin.

Integrative Network Pharmacology, Molecular Docking, and Dynamics Simulations Reveal the Mechanisms of in Diabetic Nephropathy Treatment: An In Silico Study.

Diabetic nephropathy (DN) is a serious diabetes-related complication leading to kidney damage. (CT), traditionally used in managing diabetes and kidney disorders, has shown potential in treating DN, although its active compounds and mechanisms are not fully understood. This study aims to identify CT's bioactive compounds and explore their therapeutic mechanisms in DN.

Application of central composite design for commercial laundry wastewater treatment by packed bed electrocoagulation using sacrificial iron electrodes.

This research paper deals with a novel method utilizing packed bed electrocoagulation (PBEC) comprising of sacrificial iron electrodes and coupled with extracellular polymeric substances (EPS) used as flocculent agents for the treatment of commercial laundry wastewater (LWW). The study employs stainless steel cathodes, graphite anodes, and scrap iron pieces as sacrificial electrodes, ensuring efficient treatment in dynamic batch mode operation with enhanced contact time facilitated by serpentine flow. The initial characteristics of LWW were COD 579 ± 30 mg/L, TSS of 60 ± 10 mg/L, TS of 622 ± 20 mg/L, turbidity of 110 ± 5 NTU, pH of 9 ± 0.