Publications by authors named "R K Taira"
We propose a silicon photonics fiber coupler consisting of a metastructure containing a through-hole array and a partially etched grating to obtain high efficiency. Using an evolution optimization algorithm, we optimized 121 structural parameters and achieved a minimum feature size of 150 nm, which greatly simplifies the fabrication using wafer-scale foundry services. We designed two structures, one achieving an 86% coupling efficiency into a single fiber, and the other exhibiting a full flat spectrum in the C band.
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- GNAO1 encodes a protein involved in brain development, and its mutations lead to serious neurological issues such as developmental delays and seizures in infants.
- Research shows that reducing Gnao1 levels disrupts important signaling pathways and affects neuron growth, particularly in cells from patients with specific mutations.
- The study suggests that targeting the Rho GTPase pathway could be a potential therapeutic strategy for treating GNAO1-associated encephalopathy.
Article Synopsis
- The Shank3 gene, linked to autism, has several isoforms (Shank3a-f) and knockout mice lacking Shank3a/b show heightened seizure susceptibility.
- Researchers conducted a proteomic analysis that identified 348 proteins interacting with the N-terminal and ankyrin repeat domains of Shank3a/b, highlighting significant associations with RNA-binding proteins and components involved in splicing and ribosomes.
- The interaction between Shank3 and the protein Nono was validated, and knockout mice also displayed abnormal splicing of autism-related genes, suggesting Shank3 regulates RNA-binding protein interactions and gene expression in the developing brain.
Pathogenic variants in ATP1A3, the gene encoding the α3 subunit of the Na+/K+-ATPase, cause alternating hemiplegia of childhood (AHC) and related disorders. Impairments in Na+/K+-ATPase activity are associated with the clinical phenotype. However, it remains unclear whether additional mechanisms are involved in the exaggerated symptoms under stressed conditions in patients with AHC.
View Article and Find Full Text PDFObjective: This study aims to facilitate the creation of quality standardized nursing statements in South Korea's hospitals using algorithmic generation based on the International Classifications of Nursing Practice (ICNP) and evaluation through Large Language Models.
Materials And Methods: We algorithmically generated 15 972 statements related to acute respiratory care using 117 concepts and concept composition models of ICNP. Human reviewers, Generative Pre-trained Transformers 4.