HRS Improves Active Surveillance for Prostate Cancer by Timely Identification of Progression.

Rationale And Objectives: Active surveillance (AS) is the preferred management strategy for low-risk prostate cancer. This study aimed to evaluate the impact of Habitat Risk Score (HRS), an automated approach for mpMRI analysis, for early detection of progressors in a prospective AS clinical trial (MAST NCT02242773).

Materials And Methods: The MAST protocol includes Confirmatory mpMRI ultrasound fusion (MRI-US) biopsy and yearly surveillance MRI-US biopsies for up to 3 years.

Assessing the Molecular Heterogeneity of Prostate Cancer Biopsy Sampling: Insights from the MAST Trial.

Background And Objective: Prostate cancer (PC) heterogeneity can result in sampling discrepancies during biopsy, leading to inaccurate molecular classifications that affect treatment decisions. We evaluated transcriptomic profile variability between multiparametric magnetic resonance imaging (mpMRI)-targeted biopsy (TBx) and systematic biopsy (SBx) methods using the Decipher GRID platform.

Methods: The study included 205 men from the MAST trial.

Evaluation of the Effect of Precursor NMC622@TiO Core-Shell Powders Using a Prelithiated Anode from Fig Seeds: Spotlight on Li-ion Full-Cell Performance.

In this study, innovative electrode materials for lithium-ion batteries (LIBs) were developed and characterized, demonstrating significant performance enhancements. Initially, NMC622@TiO was synthesized using a wet-chemical method with titanium(IV) ethoxide as the Ti source. Advanced structural investigations confirmed the successful formation of a core@shell structure with negligible cation mixing (Li/Ni) at the NMC622 surface, contributing to enhanced electrochemical performance.

Integrated framework for quantitative T2-weighted MRI analysis following prostate cancer radiotherapy.

Purpose: The aim of this study is to develop a framework for quantitative analysis of longitudinal T2-weighted MRIs (T2w) following radiotherapy (RT) for prostate cancer.

Materials And Methods: The developed methodology includes: deformable image registration of longitudinal series to pre-RT T2w for automated detection of prostate, peripheral zone (PZ), and gross tumor volume (GTV); and T2w signal-intensity harmonization based on three reference tissues. The gistration and onization () framework was applied on T2w acquired in a clinical trial consisting of two pre-RT and three post-RT MRI exams.

Dynamics of Daily Glioblastoma Evolution During Chemoradiation Therapy on the 0.35T Magnetic Resonance Imaging-Linear Accelerator.

Purpose: Glioblastoma changes during chemoradiation therapy are inferred from magnetic resonance imaging (MRI) before and after treatment but are rarely investigated due to logistics of frequent MRI. Using a combination MRI-linear accelerator (MRI-linac), we evaluated changes during daily chemoradiation therapy.

Methods And Materials: Patients with glioblastoma were prospectively imaged daily during chemoradiation therapy on 0.