Publications by authors named "R K Sahay"
Article Synopsis
- Graves' disease (GD) is an autoimmune disorder where the body's antibodies stimulate the TSH receptor, causing excessive thyroid hormone production.
- Diagnosis typically involves assessing symptoms and a thyroid panel, with specific tests for TSH Receptor Antibodies (TRAbs) aiding in diagnosis and management strategies.
- Recent guidelines from experienced endocrinologists emphasize the importance of TRAbs in GD management to improve effectiveness and decision-making for healthcare providers, particularly in South Asia.
Kerala, a south Indian state witnessed several outbreaks of Nipah encephalitis since 2018, a zoonotic viral disease with significant pandemic potential. This review highlights the relevance of surveillance and health system preparedness, infection control, early diagnosis and treatment with broad-spectrum antivirals, environmental conservation, and community engagement in mitigating Nipah outbreaks. Additionally, it emphasises the importance of developing new biologicals and anti-viral drugs to combat the disease.
View Article and Find Full Text PDFIntroduction: A slower adoption rate of fixed dose combinations (FDC) in diabetes management is partly due to insufficient data. This study evaluates the safety and efficacy of an FDC of dapagliflozin + sitagliptin + metformin hydrochloride extended release (XR), compared to a dual FDC of sitagliptin + metformin hydrochloride XR among patients with type 2 diabetes mellitus (T2DM) with poor glycemic control when treated with metformin monotherapy.
Methods: A total of 274 patients with T2DM were randomized (1:1) to either arm X, receiving FDC of dapagliflozin (10 mg) + sitagliptin (100 mg) + metformin hydrochloride XR (1000 mg) (Dapa + Sita + Met) tablets, or arm Y, receiving sitagliptin phosphate (100 mg) + metformin hydrochloride XR (1000 mg) (Sita + Met) tablets, and treated for 16 weeks.
Article Synopsis
- * The study examined the expression of p53 and E-cadherin in a group of 50 confirmed UC cases, using immunohistochemical methods to identify correlations with tumor grade and clinicopathological features.
- * Results showed that high-grade UC was prevalent and associated with low E-cadherin expression, indicating a potential relationship between reduced E-cadherin and tumor invasiveness, while elevated p53 was observed in all cases, suggesting its role in cancer progression.