Children and adolescents' perceptions of childhood neglect: Content and thematic analyses of childline message boards.

Background: Neglect is the most common form of child maltreatment. Its detrimental impact on individuals' physical, psychological, and social functioning is felt by the whole of society. Despite being neglect's subjects, children are only recently included in its research.

Air-conduction and bone-conduction reference threshold levels-A multicenter studya).

Air-conduction (AC) and bone-conduction (BC) thresholds were measured to evaluate standard reference thresholds and recommend revisions to audiometer standards. AC and BC thresholds were measured from listeners with normal hearing (NH) and sensorineural hearing loss (SNHL) at three sites. NH participants (n = 53) were selected based on age (18-25 years old), normal AC thresholds, tympanometry, otoscopy, and absence of otologic disease.

Identification of human pregnane X receptor antagonists utilizing a high-throughput screening platform.

Pregnane X receptor (PXR) is a xenobiotic-sensing nuclear receptor with a well-established role in regulating drug metabolism and clearance. Recent studies have shown that PXR is involved in cell proliferation, apoptosis, immune response, and energy homeostasis. It is important to identify compounds that may modulate PXR activity to prevent drug-drug interactions, distinguish chemicals which could potentially generate toxicity, and identify compounds for further development towards therapeutic usage.