Impact of Axial Orbital Depth on Extraocular Muscle Diameter Changes Following Retrobulbar Glucocorticoid Injection in Graves Ophthalmopathy: A Retrospective Cohort Study.

Objective: The objective of this study was to explore the impact of the bony orbit on the alteration of extraocular muscle diameters (EMDs) following retrobulbar injection of glucocorticoids (GCs) in patients with Graves ophthalmopathy (GO), which is a common therapeutic approach.

Methods: Retrospective collection and analysis of data were conducted on GO patients who underwent retrobulbar GC injection. Measurements of bony orbital dimensions before and after injection were acquired through orbital computed tomography.

Emergence of plasmid-mediated fosfomycin resistance among harboring , (X4), and genes in wild birds.

Unlabelled: Fosfomycin represents a last-line reserve antibiotic for the treatment of infections caused by multidrug-resistant (MDR) bacteria. Nevertheless, the advent of plasmid-mediated fosfomycin resistance among bacteria from humans and food animals incurs great concern. This study reports the detection and genomic portrait of the plasmid-mediated fosfomycin resistance gene, , amid from wild birds co-harboring plasmid-mediated tigecycline resistance gene(X4), and colistin resistance gene, .

High-Coverage Stereoproteome Mapping Uncovers Pervasive Protein Stereoisomerization Associated with Neurodegeneration.

Protein asymmetry, while crucial for life, can arise from subtle stereoisomerization. However, a comprehensive understanding of the breadth and specificity of the whole stereoproteome (STEP) has been hindered by insufficient stereoisomeric resolution. Here, we introduce an untargeted, STEP discovery protocol for comprehensive STEP profiling and relative quantification.

Thirty-Day Endovascular Repair Outcomes of Stanford Type B Aortic Dissection in Patients With Diabetes Mellitus: A Propensity-Score-Matched Study From the ACS-NSQIP Database.

Background: The surgical intervention for Stanford type B aortic dissection (TBAD) has been revolutionized by thoracic endovascular aortic repair (TEVAR). While diabetes mellitus (DM) is associated with increased risks of short-term mortality and infectious complications after major surgeries, previous studies present conflicting findings regarding the outcomes of TEVAR in DM patients. This study aimed to assess the 30-day postoperative outcomes for DM patients who have undergone TEVAR for TBAD using a dataset from a multi-institutional national registry.

The Basilar Artery Collateral Simplified Score: a Novel Collateral Circulation Score Associated With Outcomes in Patients With Basilar Artery Occlusion: Results From the ATTENTION Study.

Background: The aim of the current study was to develop a simplified collateral score for basilar artery occlusion and assess its impact on the relationship between procedure time and outcomes.

Methods And Results: The derivation cohort (n=221) from the ATTENTION (Endovascular Treatment for Acute Basilar Artery Occlusion) study was used. Variables identified by logistic regression were used to develop the Basilar Artery Collateral Simplified Score (BACSS).