Publications by authors named "R K Kopperud"
Liquid biopsies have emerged as a potential new diagnostic tool, providing detailed information relevant for characterization and treatment of solid cancers. We here present an overview of current evidence supporting the clinical relevance of liquid biopsy assessments. We also discuss the implementation of liquid biopsies in clinical studies and their current and future clinical role, with a special reference to the Nordic healthcare systems.
View Article and Find Full Text PDFCross-Cancer Genome-Wide Association Study of Endometrial Cancer and Epithelial Ovarian Cancer Identifies Genetic Risk Regions Associated with Risk of Both Cancers.
Cancer Epidemiol Biomarkers Prev
January 2021
Background: Accumulating evidence suggests a relationship between endometrial cancer and ovarian cancer. Independent genome-wide association studies (GWAS) for endometrial cancer and ovarian cancer have identified 16 and 27 risk regions, respectively, four of which overlap between the two cancers. We aimed to identify joint endometrial and ovarian cancer risk loci by performing a meta-analysis of GWAS summary statistics from these two cancers.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the role of Epac1 in kidney function, specifically its effects on diuresis and osmolyte transport in the collecting duct of mice.
- Findings show that Epac1 mice exhibit increased urine production and alterations in cellular structures, which contribute to their ability to maintain kidney osmolarity and prevent excessive fluid loss.
- The results confirm the hypothesis that Epac1 helps protect against diabetes insipidus by supporting the integrity of cell junctions in the renal papillae.
Innate drug sensitivity in healthy cells aids identification of lineage specific anti-cancer therapies and reveals off-target effects. To characterize the diversity in drug responses in the major hematopoietic cell types, we simultaneously assessed their sensitivity to 71 small molecules utilizing a multi-parametric flow cytometry assay and mapped their proteomic and basal signaling profiles. Unsupervised hierarchical clustering identified distinct drug responses in healthy cell subsets based on their cellular lineage.
View Article and Find Full Text PDFPurpose: Valproic acid (VPA) is suggested to be therapeutically beneficial in combination with interferon-alpha (IFNα) in various cancers. Therefore, we examined IFNα and VPA alone and in combinations in selected AML models, examining immune regulators and intracellular signaling mechanisms involved in phospho-proteomics.
Methods: The anti-leukemic effects of IFNα and VPA were examined in vitro and in vivo.