Understanding the structural and functional implications of lysine succinylation in Mycobacterium tuberculosis heat shock protein 16.3.

Heat shock protein 16.3 (Hsp16.3), a major immunodominant antigen of Mycobacterium tuberculosis, exhibits molecular chaperone function that is essential for pathogen's survival and slow growth inside hosts, as well as for enhancing the efficacy of Bacillus Calmette-Guérin (BCG) vaccine.

Predictive value of platelet function assays in traumatic brain injury patients on antiplatelet therapy.

Introduction: Traumatic brain injury (TBI) patients on antiplatelet therapy face higher mortality because of impaired platelet function, which may be treated by platelet transfusion. The value of testing platelet function in this cohort remains controversial. We aimed to evaluate the relationship between platelet function assays and outcomes in TBI patients on antiplatelet therapy receiving platelet transfusions.

Utility of fine-needle aspiration cytology combined with flow cytometry in extramedullary hematolymphoid lesions - A cross-sectional study.

Objective: Flow cytometry (FC) can be an adjunct to fine-needle aspiration cytology (FNAC) in the diagnosis and subclassification of hematolymphoid lesions. This study evaluates the utility of FC in diagnosing extramedullary hematolymphoid lesions in fine-needle aspirate samples.

Material And Methods: This cross-sectional study enrolled patients who presented to the FNAC clinic and suspected to have hematolymphoid lesions (nodal and extra nodal lesions) from August 2020 to June 2022.

Liquid biopsy for diagnosing epithelial ovarian cancer: quantification of cell-free DNA and p53 mutational analysis.

Objective: To isolate and quantify cell-free DNA, analysis for p53 mutations, and correlation with tumor burden in women with epithelial ovarian cancer compared with benign and borderline epithelial ovarian tumors.

Methods: In this case-control study, plasma samples of eligible women collected 1 hour before surgery and based on final histopathology, women with epithelial ovarian cancer recruited as cases and borderline, and benign ovarian tumors as controls. Cell-free DNA extracted from plasma serum and quantified using Nanodrop Spectrophotometer.

Estimating the structural and spatial variables of allantoinase enzyme critical for protein adsorption.

Designing enzyme-based sensors necessitates a comprehensive exploration of macromolecular properties. Integrating enzymes with a suitable transducer involves immobilizing them onto a surface, facilitated through adsorption or entrapment techniques. Allantoin, a stable biomarkers metabolite, holds promise for detecting oxidative stress-related complications through its enzyme.