Publications by authors named "R K Gajbhiye"
Analytical quality by design guided white analytical chemistry driven green in the development of LC-ICP-MS method for arsenic speciation analysis in HEK-293 cells.
J Chromatogr B Analyt Technol Biomed Life Sci
January 2025
An analytical quality by design-guided LC-ICP-MS method for simultaneous arsenic speciation analysis in HEK-293 cells was optimized and validated. Initially, critical method variables (CMVs) were identified to achieve the targeted critical quality attribute (CQA) of the analytical target profile (ATP). Based on knowledge and risk assessments, formic acid (X), citric acid (X), and pH (X) were studied for their effect on method responses such as resolutions (Y1, Y2) and retention time of As(V), As(III) and DMA (Y3, Y4, and Y5) using central composite design (CCD).
View Article and Find Full Text PDFNational Action Plan for the prevention and control of snakebite envenoming in India: strategies and challenges.
Trans R Soc Trop Med Hyg
January 2025
Article Synopsis
- India has the highest incidence of snakebite deaths globally, prompting the launch of a National Action Plan to combat this issue.
- The plan focuses on providing universal access to antivenom, improving healthcare, training professionals, and involving traditional healers to raise public awareness.
- It emphasizes collaboration across sectors, allows for state-specific strategies, and highlights the importance of ongoing political support, monitoring, global partnerships, and community engagement for successful implementation.
Introduction: The last decade has witnessed several modifications in the laparoscopic techniques for ventral hernia. The aim of this study was to compare an established repair such as laparoscopic intraperitoneal onlay mesh repair with defect closure (IPOM plus) with subcutaneous onlay endoscopic approach (SCOLA) for medium ventral hernia.
Patients And Methods: From June 2019 to November 2021, 29 patients undergoing IPOM plus and 22 patients undergoing SCOLA for medium ventral hernia (umbilical and epigastric hernia of size 2-4 cm) were included in the study.
Article Synopsis
- - This study investigates the health benefits of ripe Meyna spinosa fruit extracts, focusing on their abilities to act as antioxidants, antiproliferatives, and anti-inflammatories, supported by chemical analysis identifying key bioactive compounds.
- - The ethyl acetate extract showed the highest antioxidant activity, while both ethyl acetate and methanol extracts reduced cancer cell growth significantly and demonstrated strong anti-inflammatory effects by decreasing levels of various inflammatory markers in immune cells.
- - In animal models, the ethyl acetate extract effectively reduced swelling from carrageenan-induced inflammation by 23.45%, suggesting potential therapeutic applications for inflammation and cancer treatment.
heartwood is well acknowledged for its medicinal properties and use in the furniture and handicraft industries. Owing to its medicinal properties, the present investigation aims to isolate and characterize the secondary metabolites from the heartwood. The investigation led to the isolation of one undescribed dehydropterocarpan and eleven known compounds.
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