Publications by authors named "R K Foreman"
Sinonasal mucosal melanoma (SNMM) is a rare aggressive tumor often diagnosed at advanced stage. SNMM is associated with a greater than 50% rate of recurrence and a disease-specific 5 year survival rate of less than 25%. Sinonasal anatomy may contribute to difficulty in early detection; SNMM is usually asymptomatic until bulky and polypoidal.
View Article and Find Full Text PDFBackground: Enteroendocrine cells (EECs) produce over 20 gut hormones which contribute to intestinal physiology, nutrient metabolism and the regulation of food intake. The objective of this study was to generate a comprehensive transcriptomic map of mouse EECs from the stomach to the rectum.
Methods: EECs were purified by flow-cytometry from the stomach, upper small intestine, lower small intestine, caecum and large intestine of NeuroD1-Cre mice, and analysed by single cell RNA sequencing.
Article Synopsis
- - In their 2016 white paper, the authors detailed the structure and function of cardiac autonomic control and its changes in disease, proposing ways to utilize this knowledge for therapy.
- - This update emphasizes advancements in the field, exploring the challenges and possibilities for translating research into practical treatments, particularly regarding imbalances in autonomic responses that can lead to heart issues.
- - The authors advocate for the development of sensor technology to monitor specific biomarkers, aiming to create closed-loop autonomic regulation therapies that work alongside the body's natural control systems for better health outcomes.
Phenol red is commonly used in cell culture media, but can be detrimental to bioanalysis of samples as it may impact instrument reliability. Many researchers do their final stage of culture in 'phenol red free' media, but in collaborative work this is not always feasible. A comparison was made between typical extraction methods to reduce phenol red matrix interferences, including organic solvent precipitation and solid phase extraction.
View Article and Find Full Text PDFComparing the Memory Effects of 50-Hz Low-Frequency and 10-kHz High-Frequency Thoracic Spinal Cord Stimulation on Spinal Neural Network in a Myocardial Infarction Porcine Model.
Neuromodulation
October 2024
Objective: This study evaluated the effects of cessation of both conventional low-frequency (50 Hz) and high-frequency (10 kHz) spinal cord stimulation (SCS) on the cardiospinal neural network activity in pigs with myocardial infarction (MI). The objective is to provide an insight into the memory effect of SCS.
Materials And Methods: In nine Yorkshire pigs, chronic MI was created by delivering microspheres to the left circumflex coronary artery.