Publications by authors named "R K Dhillon-Smith"
Objective: To examine the association between periconceptual maternal diet and miscarriage risk among women with recurrent miscarriages.
Design: Prospective multicentre cohort study (Tommy's Net).
Setting: Three university hospital research centres in the United Kingdom.
Article Synopsis
- * The study analyzed data from 65,559 participants across 25 cohorts, focusing on risk factors like maternal age, BMI, and antibody positivity while excluding those with pre-existing thyroid issues.
- * Results indicated a screening rate of 58% among high-risk cohorts, with minimal variation in risk for hypothyroidism based on age and BMI, and TPOAb/TgAb positivity significantly correlated with higher risks for overt and subclinical hypothyroidism.
Myoinositol or D-chiro-inositol for PCOS symptoms in adolescents: a narrative review.
J Pediatr Endocrinol Metab
February 2024
Background: Polycystic ovary syndrome (PCOS) treatment in adolescents currently focuses on lifestyle interventions, with pharmacological treatment options often limited to hormonal contraceptives. Several of these carry broad side-effect profiles and are not always accepted by young girls. There is growing interest in non-hormonal therapies for PCOS.
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- Morphokinetic models, specifically the PREFER and LB models, show better ability to prioritize euploid embryos for transfer compared to traditional embryologist selection.
- Study data was collected from 1958 biopsied blastocysts across nine IVF clinics in the UK over two years, analyzing various selection methods' effectiveness.
- Results indicate that the morphokinetic models had higher ranking success for euploid embryos (47% for PREFER) compared to embryologist selection (39%) and arbitrary selection (37%), with significant statistical differences.
Article Synopsis
- * Recent big data studies have identified specific gene mutations linked to both sporadic and recurrent miscarriages beyond just embryonic aneuploidy.
- * The article reviews the genetic factors involved in miscarriage and discusses how to diagnose and prevent genetic causes of both sporadic and recurrent pregnancy loss.