Impact of co-infections and immune responses on clinical severity of human adenovirus 3 and 7 infections in hospitalized children with lower respiratory tract infections: a comparative study.

Background: The pathogenic distribution of co-infections and immunological status of patients infected with human adenovirus serotypes 3 or 7 (HAdV-3 or HAdV-7) were poorly understood.

Methods: This study involved a retrospective analysis of respiratory specimens collected from enrolled children with lower respiratory tract infections (LRTIs), positive for HAdV-3 or HAdV-7 from January 2017 to December 2019. Demographic data, clinical features, laboratory and radiographic findings were compared to delineate the impact of co-infections, and immune responses on clinical severity of HAdV-3 or HAdV-7 infections.

Photocatalytic Oxygen Evolution with Prussain Blue Coated ZnO Origami Core-Shell Nanostructures.

The design and development of particulate photocatalysts has been an attractive strategy to incorporate earth-abundant metal ions to water splitting devices. Herein, we synthesized CoFe-Prussian blue (PB) coated ZnO origami core-shell nanostructures (PB@ZnO) with different mass ratio of PB components and investigated their photocatalytic water oxidation activities in the presence of an electron scavenger. Photocatalytic experiments reveal that the integration of PB on ZnO boosts the oxygen evolution rate by a factor of ~2.

Emergence of biphasic versus monotonic response of actin retrograde flow and cell traction force with varying substrate rigidity.

The transmission of cytoskeletal forces to the extracellular matrix through focal adhesion complexes is essential for a multitude of biological processes, such as cell migration, cell differentiation, tissue development, and cancer progression, among others. During migration, focal adhesions arrest the actin retrograde flow towards the cell interior, allowing the cell front to move forward. Here, we address a puzzling observation of the existence of two distinct phenomena: a biphasic vs a monotonic relationship of the retrograde flow and cell traction force with substrate rigidity.

A large language model in solving primary healthcare issues: A potential implication for remote healthcare and medical education.

Background And Aim: Access to quality health care is essential, particularly in remote areas where the availability of healthcare professionals may be limited. The advancement of artificial intelligence (AI) and natural language processing (NLP) has led to the development of large language models (LLMs) that exhibit capabilities in understanding and generating human-like text. This study aimed to evaluate the performance of a LLM, ChatGPT, in addressing primary healthcare issues.

Molecular Design and Alignment for Ambipolar SCLC Mobility in Self-Assembled Columnar Discogens.

The future of next-generation electronics relies on low-cost organic semiconductors that are tailored to simultaneously provide all requisite optoelectronic properties, focusing greatly on ambipolar charge-transport and solution processability. In this regard, room-temperature discotic liquid crystals (DLCs) are potential candidates, where quasi-1D self-assembly affords a charge-transport channel along their columnar axis. This work shows a molecular design strategy by utilizing anthraquinone as the primary motif, surrounded by ester functionalized tri-alkoxy phenyl units to develop room-temperature DLCs (1.