Publications by authors named "R K Burt"
Corrigendum: Organotypic culture of neonatal murine inner ear explants.
Front Cell Neurosci
November 2024
[This corrects the article DOI: 10.3389/fncel.2019.
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- Cancer-associated fibroblasts (CAFs) in B-cell precursor acute lymphoblastic leukemia (B-ALL) originate from bone marrow-derived mesenchymal stromal cells (MSCs) and are influenced by reactive oxygen species from chemotherapy.
- The study shows that exposure of MSCs to B-ALL cells or their secretions initiates the CAF formation, marked by a strong interferon pathway response.
- A key finding is that leukemia cell-derived mitochondrial double-stranded RNA (dsRNA) stimulates MSCs to transition into CAFs, and disrupting dsRNA can block this process, revealing a new way cancer cells interact with their environment.
Article Synopsis
- Identification of stearoyl-CoA desaturase (SCD) as a key therapeutic target in improving the outcomes of acute myeloid leukemia (AML) patients, showing its role across different mutational backgrounds.
- Inhibition of SCD using the drug SSI-4 induces lipotoxicity, leading to cell death in AML models both in lab conditions and in living organisms.
- The study suggests that combining SCD inhibition with standard chemotherapy enhances the effectiveness of treatment, emphasizing the need for predictive biomarkers and combination therapies for optimal results.
Autologous hematopoietic stem cell transplantation (HSCT) is associated with 5-year treatment-free remissions in approximately 80% of patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) who failed or were dependent on intravenous immunoglobulin and or plasmapheresis. Autologous HSCT was associated with significant improvement in strength, independent ambulation, quality of life, nerve conduction velocity, and compound muscle action potential amplitude. The results of HSCT are dependent on proper patient selection, i.
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