Publications by authors named "R K Bose"
Cellular prion protein (PRNP) has been implicated in various physiological processes in different cell types, for decades. Little has been known how PRNP functions in multiple, yet related processes within a particular system. In our current study, with the aid of high-throughput RNA-sequencing technique, we have presented an overall transcriptome profile of rat vascular smooth muscle cells (VSMCs) with Prnp knockdown.
View Article and Find Full Text PDFEnfortumab vedotin (EV) is used as monotherapy or combined with pembrolizumab in advanced urothelial carcinoma (aUC), but biomarker data associated with EV outcomes are limited. We identified 170 patients in the UNITE study who received EV monotherapy and had molecular biomarker data available. Outcomes for groups with and without a particular biomarker were compared using logistic regression (unadjusted) for the objective response rate (ORR), and a log-rank test and Cox proportional-hazard models (CPHMs) for progression-free survival (PFS) and overall survival (OS) from EV initiation.
View Article and Find Full Text PDFIntroduction: Consultation audio recordings improve patient decision-making but are underutilized. Patient-administered recording apps on mobile devices may increase access, but implementation has not been evaluated.
Methods: We conducted a single-arm study delivering education, coaching, and reminders for patients to record their appointment using a mobile recording app.
Article Synopsis
- - Venetoclax is an effective treatment for chronic lymphocytic leukemia (CLL) that can lead to long-lasting remissions but carries a risk of tumor lysis syndrome (TLS), which necessitates careful monitoring during treatment.
- - A study at Levine Cancer Institute examined 73 patients with CLL on venetoclax to determine how often TLS monitoring led to interventions, finding that strict adherence to monitoring occurred in 66% of cases.
- - Results showed a low incidence of TLS, with only one laboratory case reported and no clinical cases, indicating that most patients, especially those with low tumor burden, required few interventions.
Article Synopsis
- Diverse allelochemicals from plants can either stimulate or inhibit the growth of other plants, and this study focuses on the effects of Tamarindus indica L. seed exudate (TSE) on the medicinal herb, Bacopa monnieri.
- The research found that treating Bacopa monnieri seedlings with a specific concentration of TSE (1:4 seed weight:water) significantly boosted the production of secondary metabolites and genes related to bacoside biosynthesis, leading to a 1.7-fold increase in bacoside levels compared to control samples.
- The study also identified key compounds in TSE, including lupanine, chlorogenic acid, and mucic acid, as potential allelochemicals