The Influence of Tobacco Smoking Intensity on Hemodynamic Parameters: A Functional Transcranial Doppler Study on Vascular Reserve in Chronic Smokers.

Objective: Tobacco smoking is an independent risk factor for stroke. In acute and chronic settings, it affects cerebral blood flow, mean systolic velocities, changes of velocities in response to metabolic challenges, pulsatility, and resistance indices in otherwise healthy smokers. The objective of the study was to determine the influence of smoking intensity on hemodynamic parameters in nonsmokers and smokers.

Cerebral infarction as initial manifestation of meningovascular neurosyphilis in an immunocompetent patient - A case report with long term follow-up.

To present a 29-year-old immunocompetent patient with neurosyphilitic changes characterized by multiple acute ischemic brain strokes along with significant narrowing of several large intracranial arteries. Ceftriaxone treatment for 14 days followed by benzathine benzylpenicillin weekly for additional 3 weeks, showed improvement in meningovascular changes.

The first comparative double-blind trial on efficacy and safety of ergotamine based five-component combination and sumatriptan in migraine without aura.

Background: Dihydroergotamine or ergotamine are the most effective preparations for aborting acute attacks of migraine without aura.

Objective: The aim of our study was to compare the efficacy and safety of ergotamine based five-component drug combination and sumatriptan in the treatment of moderate to severe acute attacks of migraine without aura.

Methods: The study was designed as a randomized, double-blind, double-dummy, placebo-controlled, parallel arm, multi-center clinical trial.