Publications by authors named "R Jonsson"
Fritz Kauffmann (1899-1978) was a German/Danish microbiologist, who worked most of his years studying intestinal bacteria at Statens Serum Institut in Denmark. During his research, he implemented several diagnostic tools, which are still used in reference laboratories worldwide. Kauffmann was probably most known for developing the "Kauffmann-White scheme" based on the O- and flagella antigens on the surface of Salmonella.
View Article and Find Full Text PDFObjectives: To calculate a polygenic risk score (PRS) based on single nucleotide variants (SNVs) previously associated with primary Sjögren's disease (SjD) with genome-wide significance, and determine the genetic risk for SjD stratified by antibodies, sex and age at diagnosis.
Methods: Patients with SjD (n = 1065) were genotyped using Illumina OmniExpressExome chip. Control genotype data were available (n = 7742).
Article Synopsis
- This study investigates the genetics behind systemic inflammatory autoimmune diseases (SIADs), like systemic lupus erythematosus, primary Sjögren's disease, and myositis, which share similar autoantibodies and symptoms.
- Researchers sequenced DNA from immune-related genes in over 2,200 Scandinavian patients and 1,200 controls to identify genetic variants connected to these diseases.
- Findings revealed both known and new genetic loci associated with SIADs and highlighted that different patient subgroups have distinct genetic traits, influencing their clinical features and possibly leading to anti-inflammatory effects related to skin manifestations.
A black hole evaporates by Hawking radiation. Each mode of that radiation is thermal. If the total state is nevertheless to be pure, modes must be entangled.
View Article and Find Full Text PDFPsoriasis is a chronic, inflammatory skin disease characterized by a dysregulated immune response and systemic inflammation. Up to one-third of patients with psoriasis have psoriatic arthritis (PsA). Targeted treatment with antibodies neutralizing tumor necrosis factor can ameliorate both diseases.
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